| Opioids have become invaluable in modern medicine, but it is essential that they are prescribed with an understanding of the complex pharmacology behind their effectiveness. Without this, they will frequently fail to achieve their enormous potential of pain relief, minimal side effects, and improved function. In addition, opioids come with problems, including side effects such as constipation, respiratory depression, and sedation, as well as the potential for substance abuse. Clinicians handling the complex pain problems of cancer patients must incorporate the insight of basic scientists and pharmacologists, and this new edition of this comprehensive text brings together a wealth of experience from those involved in all aspects of opioids, with a view to improving both clinician understanding and patient care. The text includes comprehensive coverage of the principles of opioid pharmacodynamics, pharmacokinetics, and pharmacogenetics. A chapter is dedicated to each of the main opioids, with topics such as structure, routes of administration, toxicity, drug interactions, and effects on organ function included within each one. The book concludes with several chapters dedicated to discussion of the major issues relevant to opioid use, including substance abuse, dosing strategies for acute and chronic pain, patient controlled analgesia, equianalgesia, spinal opioids, pain that doesn't respond to opioids, and the terminal phase. This text is the most complete and extensive work available on the use of opioids for cancer pain, and is an important reference for those clinicians treating individuals with cancer. |
|
| |
| Binding: Hardcover |
| Specs: 487 pages | 2.23 Lbs |
| ISBN: 019923664X |
| ISBN-13: 9780199236640 |
| Old Edition: 0198529430 |
| Edition: 2 |
| Publisher: Oxford University Press, Incorporated | Publish Date 07/09 | Copyright 2009 |
| Series: Oxford Medical Publications |
Table Of Contents:
List of abbreviations
Opioid receptors and opioid pharmacodynamics
Mellar P. Davis, Gavril W. Pasternak
Opioid pharmacokinetics
Kenneth C. Jackson II, Mellor P. Davis, Columba Quigley
Liver disease and exogenous opioid pharmacokinerics
Mellar P. Davis
Opioids in renal failure
Janet R. Hardy
Codeine
Janet R. Hardy, Kenneth C. Jackson II
Hydrococlone
Mellar P. Davis
Tramadol
Mellar P. Davis, Paul Glare
Dextropropoxyphene
Paul Glare
Morphine
Paul Glare
Oxycodone
Paul Glare, Mellor P. Davis
The lipophilic opioids: fentanyl, alfentanil, sufentanil, and remifentanil
Anthony Hall, Janet R. Hardy
Buprenorphine
Mellar P. Davis
Methadone
Mellar P. Davis, Columba Quigley
Hydromorphone
Columba Quigley, Paul Glare
Levorphanol
Mellar P. Davis
Diamorphine
Janet R. Hardy, Columba Quigley
Oxymorphone
Paul Glare
Choice of opioids and the WHO ladder
Paul Glare
Pharmacogenetics and opioids
Joy R. Ross, Columba Quigley
Opioid rotation
Janet R. Hardy, Columba Quigley, Joy R. Ross
Equi-analgesia
Mellar P. Davis, Kenneth C. Jackson II
Dosing strategies for acute pain
Mellar P. Davis
Opioid dosing strategies for chronic pain and the management of opioid side effects
Mellar P. Davis
Patient-controlled analgesia
Mellar P. Davis
Spinal opioids in cancer pain
Costantino Benedetti, Steven Paquelet, Mellar P. Davis
Opioid poorly responsive pain, physical dependence, tolerance, and opioid-induced hyperalgesia
Mellor P. Davis
Opioids in special populations: developing countries
Mhoira Leng
Opioids in special populations: paediatric population
Ross Drake
Opioids in the terminal phase
Janet R. Hardy
Cancer pain and substance abuse
Kenneth L. Kirsh, Tatiana D. Starr, Lauren J. Rogak, Steven D. Passik
Index |
| |
|
| |
|
|
|